2020 Publications | Di Paola Lab | Washington University in St. Louis

A Mathematical Model of Coagulation Under Flow Identifies Factor V as a Modifier of Thrombin Generation in Hemophilia A

Link KG, Stobb MT, Sorrells MG, Bortot M, Ruegg K, Manco-Johnson MJ, Di Paola JA, Sindi SS, Fogelson AL, Leiderman K, Neeves KB. A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A. J Thromb Haemost. February 2020; 18(2):306-317.

An International Survey to Inform Priorities for New Guidelines on Von Willebrand Disease

Kalot MA, Al-Khatib M, Connell NT, Flood V, Brignardello-Petersen R, James P, Mustafa RA; VWD working group. An international survey to inform priorities for new guidelines on von Willebrand disease. Haemophilia. January 2020; 26(1):106–116.

ETV6-related Thrombocytopenia and Platelet Dysfunction

Di Paola J, Fisher MH. ETV6-related thrombocytopenia and platelet dysfunction. January 2021. Platelets. 2020;1‐3.

Glanzmann thrombasthenia: genetic basis and clinical correlates

Perez Botero J, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, Luo M, Mohan S, Ross JE, Bergmeier W, Di Paola J; ClinGen Platelet Disorder Variant Curation Expert Panel. Glanzmann thrombasthenia: genetic basis and clinical correlates. Haematologica. March 2020. pii: haematol.2018.214239.

Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation

Gupta S, Konradt C, Corken A, Ware J, Nieswandt B, Di Paola J, Yu M, Wang D, Nieman MT, Whiteheart SW, Brass LF. Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. Proc Natl Acad Sci U S A. 2020 Sep 14:202007642.

Hypermethioninemia Leads to Fatal Bleeding and Increased Mortality in a Transgenic I278T Mouse Model of Homocystinuria

Park I, Johnson LK, Cox A, Branchford BR, Di Paola J, Bublil EM, Majtan T. Hypermethioninemia Leads to Fatal Bleeding and Increased Mortality in a Transgenic I278T Mouse Model of Homocystinuria. Biomedicines. 2020 Jul 24;8(8):E244.

Pathologic Shear and Elongation Rates Do Not Cause Cleavage of Von Willebrand Factor by ADAMTS13 in a Purified System

Bortot M, Sharifi A, Ashworth K, Walker F, Cox A, Ruegg K, Clendenen N, Neeves KB, Bark D Jr, Di Paola J. Pathologic Shear and Elongation Rates Do Not Cause Cleavage of Von Willebrand Factor by ADAMTS13 in a Purified System. Cell Mol Bioeng. 2020 Jul 17;13(4):379-390.

Platelet Activation in Experimental Murine Neonatal Pulmonary Hypertension

Davizon-Castillo P, Allawzi A, Sorrells M, Fisher S, Baltrunaite K, Neeves K, Nozik-Grayck E, Di Paola J, Delaney C. Platelet activation in experimental murine neonatal pulmonary hypertension. Physiological Reports. March 2020; 8(5):e14386.

Platelet α-granules are required for occlusive high-shear-rate thrombosis

Kim DA, Ashworth KJ, Di Paola J, Ku DN. Platelet α-granules are required for occlusive high-shear-rate thrombosis. Blood Advances. 2020 Jul 28;4(14):3258-3267.